Quick Reference
Use this page only when the short answer genuinely changes the move. The table is orientation, not permission.
- Use this page when the fast answer genuinely changes the move.
- Do not let the appendix replace the full file when the stakes are high.
- The numbers here are orientation, not permission.
Use the fast answer only when it survives compression.
This page is for return visits, not first principles. Use it when the short answer genuinely changes the move. If the stakes still feel high after the table, open the full file.
Primary references behind this section’s claims and decision rules.
- DEA Drug Scheduling Drug Enforcement Administration Federal legal baseline for controlled-substance status.
- Drug Checking Kit Instructions DanceSafe Core reagent workflow and current reminder language.
- Medication Safety and Your Health Centers for Disease Control and Prevention Child-safe storage and labeling posture.
- The detection of psilocin in human urine Journal of Forensic Sciences Supports the short targeted-detection window for psilocin.
- Classic Psychedelic Coadministration with Lithium, but Not Lamotrigine, is Associated with Seizures Pharmacopsychiatry The cleanest hard-stop source behind the lithium warning and the lamotrigine distinction.
Dose Range Reference
These are the broader PsychonautWiki dose anchors, not the Starting Floor output. Starting Floor now derives a smaller first-pass band from the lower edge of these threshold ranges so the first read stays diagnostic instead of acting like a mini light dose.
Psilocybin (Dried Mushrooms - Psilocybe cubensis)
| Level | Dose Range | Expected Read |
|---|---|---|
| Threshold | 0.25-0.5g | PsychonautWiki threshold anchor for dried cubensis. |
| Light | 0.5-1g | Light psychedelic territory, not an ordinary microdose band. |
| Common | 1-2.5g | Fully psychedelic range. |
| Strong | 2.5-5g | Well beyond microdosing language. |
Potency caveat: these ranges assume average cubensis, not unusually strong material. Penis Envy and adjacent high-potency varieties can push these numbers downward fast.
LSD / Lysergamide Analogs
| Level | Dose Range | Expected Read |
|---|---|---|
| Threshold | 15µg | PsychonautWiki threshold anchor for LSD. Starting Floor stays well below this. |
| Light | 15-75µg | Low psychedelic range, not an honest first-pass microdose band. |
| Common | 75-150µg | Full psychedelic territory. |
| Strong | 150-300µg | Far outside microdosing language. |
Starting Floor now groups LSD-25 with the common prodrug lysergamides because the practical first-pass band does not differ enough to justify separate systems.
4-AcO-DMT
| Level | Dose Range | Expected Read |
|---|---|---|
| Threshold | 5mg | PsychonautWiki threshold anchor. Starting Floor stays below it. |
| Light | 7.5-15mg | Light psychedelic territory. |
| Common | 15-25mg | Well beyond microdosing language. |
Mescaline HCl
| Level | Dose Range | Expected Read |
|---|---|---|
| Threshold | 50mg | PsychonautWiki threshold anchor for oral mescaline. |
| Light | 50-200mg | Long-duration light psychedelic territory. |
| Common | 200-400mg | Well outside microdose language and expensive to overshoot. |
Conversion & Measurement Quick Math
- Volumetric LSD: one tab in 10ml means each 1ml is one-tenth of the tab’s actual content.
- Fresh-to-dried mushrooms: roughly 10g fresh equals 1g dried, but fresh dosing is less precise.
- Milligram scale floor: 1mg resolution is the minimum for powders that live in the 1-10mg zone.
- Always recalibrate: the math is only as honest as the batch assumption behind it.
Medication Red Lines - Fast Lookup
| Medication | Interaction Level | Key Risk | Full Reference |
|---|---|---|---|
| Lithium | Absolute stop | Seizure and destabilization risk. | Medications |
| Tramadol | Absolute stop | Serotonergic stacking and seizure risk. | Medications |
| MAOIs | Pair-specific red line / clinician-level caution | Hard stops: MDMA + MAOI, 5-MeO-DMT + MAOI, and ayahuasca + pharmaceutical MAOI. Other pharmaceutical MAOI cases are no-DIY chemistry reviews. | Medications |
| SSRIs / SNRIs | High caution | Often blunted effects, with non-zero serotonergic risk and taper complexity. | Medications |
| Antipsychotics | High caution | Effect blocking plus underlying psychiatric-risk signal. | Medications |
| Benzodiazepines | Moderate | Blunting and dependence dynamics. | Medications |
| Stimulants / cannabis | Moderate | Overstimulation, anxiety, or poor calibration. | Medications |
Additional Medication Interactions - Extended Table
| Medication Class | Fast Read | Why It Matters |
|---|---|---|
| Bupropion | Usually lower-risk than SSRIs, but not casual. | Seizure-threshold questions matter more than serotonin questions. |
| Mirtazapine | Often blunts or muddies the read. | Not the same serotonergic picture as an SSRI, but still complicates interpretation. |
| TCAs | High caution | Serotonergic and noradrenergic complexity; do not simplify them into “old SSRIs.” |
| Lamotrigine | Not lithium, but still not a green light. | The seizure warning signal is different, but the broader psychiatric context still matters. |
Serotonin Syndrome Quick Recognition
- Mild: agitation, sweating, tremor, dilated pupils, rapid pulse, diarrhea.
- Moderate: hyperreflexia, clonus, worsening agitation, rising temperature.
- Emergency: high fever, rigidity, seizure, delirium, loss of consciousness, irregular heartbeat.
If the picture looks moderate or worse, call emergency services and tell responders what was taken and what medications were involved.
Case Pattern Reference - Common Scenarios
- “Nothing happened on my SSRI”: more likely receptor blunting than proof that higher doses are safe.
- “I felt too stimulated on my usual ADHD meds”: stimulant stack, not mystical misfortune.
- “A new batch at the same weight felt stronger”: batch variance won the argument.
- “The test was clean, so the batch must be safe”: home screening is not purity or potency certification.
- “The panel won’t catch it, so work is low-risk”: documentation, impairment, and boards still exist.
Reagent Testing Cheat Sheet
- Ehrlich: first-pass indole screen. No purple on claimed LSD means stop calling it LSD.
- Hofmann: stronger lysergamide follow-up when one reagent is too weak a basis for trust.
- Marquis / Mecke: broader contradiction checks when the sample may not be psychedelic at all.
- Bitter tab rule: if blotter is distinctly bitter or numbing, treat it as wrong regardless of the story.
- Fentanyl reminder: no reagent tests for fentanyl. Use strips.
Storage Rules - 30-Second Version
- Dark, dry, cool, airtight beats fancy containers with sloppy handling.
- Glass beats plastic for anything you care about preserving.
- Whole dried mushrooms outlast powder. Powder outlasts careless capsules.
- Amber glass matters for LSD and other light-sensitive solutions.
- Label the container and keep it away from children, pets, roommates, and casual access.
- Mold, dampness, condensation, or a wrong smell moves you toward discard, not debate.
Detection Windows - Fast Lookup
| Substance | Standard Panel? | Specialized Urine | Blood | Hair |
|---|---|---|---|---|
| Psilocybin / psilocin | No | 24-48 hrs | Up to 15 hrs | Up to 90 days in theory, rarely relevant in routine employment. |
| LSD | No | 24-72 hrs | 6-12 hrs | Possible in theory, but less practical than people assume. |
These are detectability windows, not risk windows. The workplace file owns the larger consequence model.
Protocol Spacing Reference
| Protocol | Dose Schedule | Rest Logic |
|---|---|---|
| Fadiman | Dose → off → off → repeat | Two recovery days between doses. |
| Threshold discovery | 10 doses across roughly 4 weeks | Minimum two days between doses during calibration. |
| Stamets | 4 on → 3 off | Higher exposure pattern. Not automatically “advanced.” |
Emergency Protocol - Distilled
If someone is in physical danger: call 911 or your local emergency number and tell responders what was taken.
If the experience is difficult but not dangerous: slow breathing, change the environment, reduce stimulation, ground physically, drink water, and stop adding substances.
- Emergency indicators: chest pain, dangerous temperature rise, seizure, difficulty breathing, unconsciousness, or active self-harm intent.
- Fireside Project support line: 62-FIRESIDE (623-473-7433), daily 11 a.m.-11 p.m. PT, U.S. only, peer support rather than emergency care.
Glossary - Key Terms
The lowest dose where something clearly shifts without turning the day into a light trip.
Finding the threshold for one specific batch. The number does not transfer to the next batch automatically.
Dissolving a known quantity into measured liquid so microgram-scale dosing becomes practical.
Primary receptor action behind classic psychedelic effects.
Potentially dangerous serotonin overactivation ranging from agitation and tremor to high fever and seizures.
Time required for blood concentration to fall by half. Useful for pharmacokinetics, not for designing your own taper.
A compound converted by the body into its active form, such as psilocybin to psilocin or 1P-LSD to LSD.
Reducing avoidable risk rather than pretending abstinence is the only reality people live in.
Read The Full File
The appendix should shorten the route to the dense page you actually need, not replace it.