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Chapter 11 • The Discovery Protocol

Discovery Journal

Build one bounded ten-dose run so a working center has to earn itself.

Full chapter Chapter 11 • The Discovery Protocol

Part of Chapter 11. Use the chapter when you need the full calibration sequence and interpretation logic.

Discovery Journal

Build one bounded ten-dose run before you claim you know your range.

Planning only
Run size10 doses

What This Run Gives You

This is not a habit tracker. It is one bounded run meant to find a believable working number and a real upper edge.

Shape

4 baseline entries, then 6 context entries.

First Number

0.05g for dose 1.

Update Rule

Only the next dose moves. The rest stays provisional.

Pick The Compound

Start with the actual molecule. A run built on the wrong compound just gets more wrong with better notes.

Set Entry Floor

Only dose 1 is real right now. Every later entry stays soft until a real log earns a change.

Start at the floor, not the fantasy. Dose 1 is a humble first pass, not a performance target.

Later doses are not promises. They only become real after you log what actually happened.

g
Entry floor: 0.05g

Choose The Cadence

MWF is still the cleanest baseline. Only pick a stranger rhythm if you can still tell what the dose is doing.

The run is still a ten-dose map. This only chooses the spacing pattern you want to test it under.

Saved only in this browser so you can come back to it. Shared machine or borrowed laptop: clear it when you are done.

What You Get

One bounded run that can find a floor clue, a working number, and sometimes an upper edge.

How It Moves

Four entries to find the range, six to see whether the range survives context.

What Wins

Your notes should beat memory, one lucky day, and the urge to call it solved too early.

Current Read

Dose 1 is 0.05g. It comes from shared dose registry default and stays below the 0.25 g to 0.5 g threshold anchor from PsychonautWiki: Psilocybin mushrooms.

Run Artifact

Build one bounded run before you start talking like you know the range.

This is a bounded calibration run, not a forever tracker: four baseline entries to find the range, then six context entries to see whether life changes the landing.

Run shape
4 baseline + 6 context
Choose molecule

Pick the actual compound first so the floor starts from honest chemistry.

Set the floor

Carry a conservative first number into the run. Dose 1 is data, not a target.

Choose cadence

MWF is the clean baseline. Alternate cadences only count if you can still defend the map.

Psilocybin mushrooms (dried)MWF baseline
Entry floor
0.05g
Cadence
MWF baseline
Floor source
Shared dose registry default
Threshold anchor
0.25 g to 0.5 g
Storage
Local browser only
Floor Source

Dose 1 is 0.05g. It comes from shared dose registry default and stays below the 0.25 g to 0.5 g threshold anchor from PsychonautWiki: Psilocybin mushrooms.

Next-Dose Rule

Barely felt it = add 0.025 g. Pretty much the number = hold. More than I wanted = subtract 0.025 g. Way too loud = subtract 0.05 g and rebuild lower.

Confidence Rule

Defended read = at least 2 pretty-much-the-number entries across 8 or more logged doses. Working read = at least 1 across 5 or more logged doses. Earlier than that, keep mapping.

Uses

Starting Floor carryover, one-dose-at-a-time update rules, and whatever signal actually shows up across the run.

Limits

Ten entries still cannot erase batch drift, context noise, or hidden chemistry problems on their own.

Next move

Use the finished run to pressure-test the working center, then stop tuning once the read is genuinely defended.

Discovery Run data stays in this browser unless you export it. Use export before clearing storage or switching devices.

Next move

Set the run up cleanly first. Discovery Journal is for learning from ten doses, not for bulldozing through chemistry questions or a messy day.

Run the first-pass checksMake sure the day-level basics are handled before you commit to the run.Check MedicationsDo not build a ten-dose run on top of unresolved chemistry.Set Starting FloorBring in a humble first number before you generate the sequence.
Protocol evidenceView sources

Physiology and context move the landing

May 1, 2026Mostly durable physiology; individual state still needs current judgment

Body weight is a weak predictor, while hormones, sleep, stress, cannabis, and cluster-specific use cases change how the same nominal dose lands.

Reference note

Directly supports the claim that body weight is a weak predictor of psilocybin response and should not anchor dose advice.

Garcia-Romeu A, Barrett FS, et al. Body weight and psilocybin response — pooled analysis from Johns Hopkins psilocybin studies. 288 subjects, weight range 49–113kg, 2.3-fold spread. No meaningful relationship between weight and subjective effects. Bayesian analysis by Imperial College (77 participants) confirmed BMI does not predict intensity.
Reference note

Supports the claim that menstrual-cycle state can move receptor behavior and therefore change how the same dose lands.

Menstrual cycle and 5-HT2A receptor modulation. Referenced in *ACS Pharmacology & Translational Science*. 2025.

Setup only

Want the longer reasoning? 11 • The Discovery Protocol/Next toolStarting Floor

Set a conservative first-pass band for a new substance, batch, or reset.